The important things you need to know Degarelix powder uses,dosing,side effect for injection

1. What is Degarelix?

Degarelix powder is used for the treatment of advanced prostate cancer. It sold under the brand name Firmagon among others. Degarelix powder (214766-78-6) is a synthetic peptide derivative powder, degarelix peptide sequence is Ac-D2Nal-D4Cpa-D3Pal-Ser-4Aph(L-Hor)-D4Aph(Cbm)-Leu-Lys(Ipr)-Pro-DAla-NH2. Degarelix binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH) which ultimately causes testosterone suppression. Reduction in testosterone is important in treating men with advanced prostate cancer.

2. Degarelix mechanism of action

Degarelix is a GnRH antagonist. In general, an antagonist drug blocks the receptor by binding to it and counteracts its function.

Degarelix inhibits GnRH from binding to its receptors and stops the release of gonadotropin. By blocking the GnRH receptors, degarelix inhibits the sex hormones' activity and decreases the production of testosterone. Since testosterone stimulates the growth of prostate cancer, the reduction of testosterone improves the prognosis of prostate cancer and decreases its size.

3. What is the drug degarelix used for?

Degarelix is a man-made form of a protein that reduces the amount of certain hormones in the body, including testosterone. Degarelix injection is used to treat prostate cancer. It works by decreasing the amount of testosterone in the body, which the tumor needs to grow.

4. What are the side effects of degarelix?


injection site reactions (pain, redness, swelling, and a hard lump),
hot flashes (flushing),
weight gain,
increased sweating,
night sweats,
back or joint pain,
chills,
tiredness,

5. How to use Degarelix? Degarelix injection dosing?

Degarelix is a Gonadotropin-releasing hormone (GnRH) receptor antagonist. It binds reversibly to the pituitary GnRH receptors, thereby reducing the release of gonadotropins and consequently testosterone.

Degarelix powder is specifically indicated for the treatment of advanced prostate cancer.

Peptide Degarelix is supplied as a powder to be reconstituted with sterile water for subcutaneous administration in the abdomen.

How to give degarelix, the recommended initial dose of the degarelix is 240 mg given as two subcutaneous injections of 120 mg at a concentration of 40 mg/mL. The recommended maintenance dose of Degarelix is 80 mg given as one subcutaneous injection at a concentration of 20 mg/mL, every 28 days.

Warning:  After you receive a dose of degarelix injection, be sure that your belt or waistband does not put pressure on the place where the medication was injected.


6. Degarelix injections


Firmagon is a sterile lyophilized powder for injection containing degarelix powder (as the acetate) and mannitol. Peptide Degarelix powder is a synthetic linear decapeptide amide containing seven unnatural amino acids, five of which are Damino acids. The acetate salt of degarelix is a white to off-white amorphous powder of low density as obtained after lyophilization. Degarelix can buy on line, the cost for peptide degarelix powder is a little bit expensive than most of the peptide powder.

Degarelix injection is used to treat advanced prostate cancer (cancer that begins in the prostate [a male reproductive gland]). Degarelix injection is in a class of medications called gonadotropin-releasing hormone (GnRH) receptor antagonists.



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